Open up the task manager (or press ctrl-alt-del on win98) end task/end process every last thing you can. You won't be able to stop a lot of stuff on Windows NT 2000 XP; that's normal... You may not want to stop explorer process on any windows....
Don't reboot... it'll just start everything up again.
At this point you have hopefully stopped all the virus processes or at least enough of them that you can get your virus scan up and running in order to clean it up.
Let me know how you make out.
Hudson
Kill the bug
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